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Rebetol | Generic

Rebetol (ribavirin) is an antiviral drug. It is used in combination with interferon for the treatment of chronic hepatitis C. Although the exact mechanism of its action is unknown, it is thought to interfere with the production and/or action of viral DNA and RNA which are critical to the survival and multiplication of the virus.

Generic Rebetol may also be marketed as: Ribavirin, Copegus, RibaPak

*Rebetol® is a registered trademark of Merck.


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Ribavirin capsules are used in combination with interferon to treat patients with chronic hepatitis C who have not been treated with interferon previously or who have had a return of hepatitis C following successful treatment with interferon.

Take this medication by mouth usually twice daily with food or as directed by your doctor. The dosage and length of treatment is based on your weight, medical condition, and response to therapy. Antiviral medications work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. It is recommended that female patients or female partners of male patients take a pregnancy test before starting this medication. A pregnancy test should also be taken every month while using this medication and for 6 months after treatment ends to make sure no pregnancy occurs.

The most common side effect seen with the combination of ribavirin and interferon is a flu-like syndrome consisting of body aches and pains, fever, chills, headache and malaise. The most serious side effect seen with ribavirin is anemia. Careful consideration is advised if ribavirin is used in patients with heart or circulation problems since the anemia may aggravate these conditions. Ribavirin should be avoided among patients who have severe kidney disease and have lost most of their kidneys' function. Therapy with ribavirin and interferon may aggravate psychiatric conditions or may trigger a psychiatric condition such as depression, psychosis, aggressive behavior, hallucinations, or violent behavior. Patients should be closely monitored for the development of these psychiatric conditions. Therapy with ribavirin and interferon has caused abnormalities of the thyroid gland. If these abnormalities persist and cannot be controlled by medication, it may be necessary to discontinue therapy. Other possible side effects that may occur during therapy with ribavirin and interferon are fatigue, weakness, nausea, anorexia, heartburn, insomnia, irritability, difficulty breathing, rash, itching, and alterations in taste perception.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have severe heart disease, kidney disease, blood disorders (e.g., sickle cell anemia, low hemoglobin), other types of hepatitis (e.g., autoimmune hepatitis). Before using this medication, tell your doctor or pharmacist your medical history, especially of other liver problems, heart problems, breathing problems, pancreas problems (e.g., pancreatitis), diabetes, and any allergies. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Avoid alcoholic beverages. Caution is advised when using this drug in the elderly because they may be more sensitive to its effects. Caution is advised when using this drug in children because they may be more sensitive to its effects, especially the mental/mood changes including severe depression or suicidal thoughts. This medication must not be used during pregnancy (see also Warning section). It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended.

Ribavirin used at the same time as other antiviral drugs with similar mechanisms of action may cause a condition in which lactic acid accumulates in the blood (lactic acidosis) which can lead to serious medical problems. Other such antiviral drugs include those used to manage HIV infection, for example, zidovudine (Retrovir), zalcitabine (Hivid) or stavudine (Zerit).

If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Ribavirin should be refrigerated at 2-8C (36-46F). Keep away from children and pets.