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Clomipramine

Clomipramine is a leading tricyclic antidepressant that is commonly used in the treatment of Obsessive-Compulsive Disorder (OCD) and other phobia disorders. The active ingredient in Anfranil®, Clomipramine works to restore chemical balance in the brain by enhancing mood-lightening compounds, resulting in a more stable state of mind, and an enhanced quality of life.

Clomipramine may also be marketed as: Anafranil


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Clomipramine is a tricyclic antidepressant (TCA) that's most commonly used in the treatment of Obsessive-Compulsive Disorder (OCD). One of the world's leading antidepressant, Clomipramine effectively crippling habits often associated with OCD, such as recurrent and repetitive thoughts, feelings and actions. This medication helps relieve the patient's tendency towards excessively repeated compulsions, such as obsessive cleanliness and hoarding, leading to a significantly improved quality of life. Clomipramine is often used to treat a range of disorders including: OCD, panic attacks, major forms of depression, narcolepsy, premature ejaculation, tension migraines, depersonalization disorder, bedwetting, cataplexy, and some impulse control disorders including trichotillomania. Always consult a trusted healthcare professional before using Clomipramine for both intended and alternative uses.



Always follow your doctor's instructions and the directions on your prescription label when taking Clomipramine. Do not take more than the dosage prescribed to you. Doses may vary depending on individual conditions. Consult a trusted medical professional for more information about the appropriate dosage to treat specific symptoms. Do not stop taking this medication without consulting your doctor first. Take this medication orally with food.



Always read the ingredients on the label before taking this or any other medication to ensure that there are no elements that may elicit an allergic reaction. Stop taking this medication and consult a doctor if you experience symptoms associated with allergies. Contract your doctor immediately if you experience negative behaviour or mood altering symptoms including increased anxiety, sleep paralysis, aggression, hyperactivity and increased depression and/or suicidal thoughts.

Seek immediate medical attention if you experience any of the following side effects: fever, chest pain, severe headache or migraine, accelerated heart rate, sudden numbness or weakness, lack of coordination, vision impairment, slurred speech, fainting spells, easy bruising or bleeding, nausea, excessive urination, excessive perspiration, severe vomiting, discolored urination or stool, jaundice, seizures.

Clomipramine may cause the following less serious side effects: constipation, stomach upset, perspiration, drowsiness, nausea, dizziness, facial flushing, fatigue, dry mouth, changes in appetite/weight, decreased sex drive, impotence. If any of these symptoms becomes troublesome or problematic, inform your doctor.



Clomipramine is not intended for use in patients who have recently suffered from a heart attack. Consult your doctor if you have a previous history of the following medical conditions before taking this medication: heart problems, stroke, seizure, suicidal thoughts, kidney troubles, liver disease, thyroid disorders (including over activity), glaucoma, or problems concerning urination.
Your doctor should be made aware of any previous conditions of mental illness including: bipolar disorder, manic-depression, and schizophrenia before taking this medication.

Dangerous mood changes may occur within the first few weeks of taking this medication and when doses are changed. Inform your doctor if you experience an increase or occurrence of suicidal thoughts while taking this medication.

Avoid drinking alcohol while taking this medication, as it may increase the risk of certain side effects. Medications that are known to cause fatigue, such as cold medicines, muscle relaxers, antidepressants and seizure medications may further increase levels of fatigue or sleepiness while taking this medication. Some doctors discourage eating grapefruit or drinking grapefruit juice while taking this medication.

Take extra precautions while driving and operating heavy machinery while taking Clomipramine. Those taking Clomipramine should take extra precautions concerning sun protection, including using sunblock (SPF 30 or higher) and appropriate clothing. Avoid using tanning beds, and direct exposure to sunlight while on this medication.



Inform your doctor of all prescription and herbal medications that you are taking before starting to use Clomipramine. Do not take this medication if you have taken any medication containing MAO inhibitors within the last 14 days, including: isocarboxazid, rasagiline, selegiline, phenelzine, and tranylcypromine. Consult your doctor if you have taken any antidepressant classified as selective serotonin re-uptake inhibitors (SSRI) over the past 5 weeks.

Talk to your doctor if you are taking any medications to treat heart problems, blood pressure, or anti-psychotics including: thioridazine, chlorpromazine, ziprasidone, quetiapine, risperidone, haloperidol, clozapine, or olanzapine.

Do not take Clomipramine if you are allergic to any similar medications such as: amoxapine, doxepin, desipramine, amitriptyline, protriptyline, trimipramine, or nortriptyline

The following medications may negatively interact with Clomipramine. Talk to your doctor if you are taking any of these medications before adding Clomipramine to your treatment plan: methylphenidate, warfarin, cimetidine, guanethidine, or phenytoin.



Never exceed the recommended dosage of Clomipramine. Missed doses should be taken as soon as the users remembers, however if it almost time for the next dosage, skip the missed dose and revert back to normal schedule. Do not take more than 2 doses of Clomipramine in one instance.



Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C). Do not store in the bathroom. Store at room temperature in a closed container protected from heat, light and moisture.Keep clomipramine away from children and pets. Always dispose of medicines safely.